Micro dose formulation mixing

Ordered mixtures are used to increase the dissolution rate of poorly soluble drugs by using a water-soluble carrier and the appropriate covering of the coarser carrier particles with drug.

In micro-dose formulations, ordered mixing increases the homogeneity of the powder blend and thus, it is used to control the content uniformity within pharmacopoeia limits in the finished dosage forms. Surface texture improvement is also beneficial in pharmaceutical and cosmetic applications. Ordered mixtures have also found their use in bio-adhesive, sublingual and other fast dissolving formulations in order to improve drug absorption.